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KMID : 0358320060470040372
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Korean Journal of Urology
2006 Volume.47 No. 4 p.372 ~ p.376
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The Changing Pattern of Serum Prostate Specific Antigen in Patients with Benign Prostatic Hyperplasia after Combined Treatment with Finasteride and α-blockers: the 3 Year Follow-up Data
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Soh Byung-Hyun
Chung Byung-Ha
Lee Jae-Seok
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Abstract
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Purpose: Some recent studies have demonstrated that finasteride, a well- known 5α-reductase inhibitor, can decrease prostate specific antigen(PSA) by approximately 50% during the first 1 year of treatment. We investigated how long-term treatment with finasteride and α-blockers impacts on the serum PSA level of men whose final diagnosis was benign prostatic hyperplasia(BPH).
Materials and Methods: In a retrospective trial, we evaluated a total of 293 men with lower urinary tract symptoms(LUTS) that were suggestive of BPH. These men were divided into two treatment groups: group A was treated with α-blockers and group C was treated with a combination of finasteride and α-blocker. Comparisons of the two groups were performed by using independent t-tests. The changes in the PSA concentrations from baseline to the time of the final measurements were determined by repeated measures of ANOVA.
Results: There was no significant difference in the baseline PSA between the two groups. A statistically significant reduction in the PSA levels was observed at 2 years in C group(p＜0.05), whereas any significant increase were not observed in group A(p＞0.05). In group A, the repeatedly measured PSA levels were 2.67, 2.40, 2.41 and 2.42, respectively. In C group, these were 3.22, 2.09, 1.81 and 1.71 respectively.
Conclusions: Our data showed that there was no clinically significant effect of long term treatment with α-blocker on the PSA levels. However, finasteride had significant effect on the serum PSA level during first two years of treatment. (Korean J Urol 2006;47:372-376)
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KEYWORD
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Prostatic hyperplasia, Adrenergic antagonist, Reductase, Prostate specific antigen
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